Predictors of Evacuation Rates during Hurricane Laura: Weather Forecasts, Twitter, and COVID-19

Machine learning was applied to predict evacuation rates for all census tracts affected by Hurricane Laura. The evacuation ground truth was derived from cellular telephone–based mobility data. Twitter data, census data, geographical data, COVID-19 case rates, the social vulnerability index from the Centers for Disease Control and Prevention (CDC)/Agency for Toxic Substances and Disease Registry (ATSDR), and relevant weather and physical data were used to do the prediction. Random forests were found to perform well, with a mean absolute percent error of 4.9% on testing data. Feature importance for prediction was analyzed using Shapley additive explanations and it was found that previous evacuation, rainfall forecasts, COVID-19 case rates, and Twitter data rank highly in terms of importance. Social vulnerability indices were also found to show a very consistent relationship with evacuation rates, such that higher vulnerability consistently implies lower evacuation rates. These findings can help with hurricane evacuation preparedness and planning as well as real-time assessment. © 2023 American Meteorological Society.

Identification of covid-19 severity and associated genetic biomarkers based on scrna-SEQ data

Bio-marker identification for COVID-19 remains a vital research area to improve current and future pandemic responses. Innovative artificial intelligence and machine learning-based systems may leverage the large quantity and complexity of single cell sequencing data to quickly identify disease with high sensitivity. In this study, we developed a novel approach to classify patient COVID-19 infection severity using single-cell sequencing data derived from patient BronchoAlveolar Lavage Fluid (BALF) samples. We also identified key genetic biomarkers associated with COVID-19 infection severity. Feature importance scores from high performing COVID-19 classifiers were used to identify a set of novel genetic biomarkers that are predictive of COVID-19 infection severity. Treatment development and pandemic reaction may be greatly improved using our novel big-data approach. Our implementation is available on https://github.com/aekanshgoel/COVID-19-scRNAseq. © 2022 Owner/Author.

Using Machine Learning Techniques to Explore the Possibilities of Reducing the Spread of Corona Virus and its New Variants

The Corona pandemic has been around for a while, and its threat to the world is growing. We believe that climate parameters and health prevention measures could be related to the number of reported Corona daily cases. In the literature there were different views on the nature of these relations using several datasets recorded from various parts of the world. In our research, data collected from zones with concentrated Corona cases: China, Europe and the United States were analyzed to understand the relation with climate as well as data at the global level to understand the relation with health prevention measures. Feature importance analysis revealed that temperature is the most important contributing attribute to the Corona cases' prediction models, followed by relative humidity. As well, the percentage of mask use and percentage of fully vaccinated individuals were found to have a great influence on the number of new Corona daily cases. The designed machine learning ensemble techniques had a maximum predication accuracy of 89.08%, and the produced possible interpretations for the designed models agreed with the performed feature importance analyses. We believe that the analysis approach followed in this research as well as the achieved findings could be very useful to other researchers who are interested in conducting more research investigation in the same research area on the new Corona variants. We also believe that policy makers could consider the findings of our research as they effectively plan their future health precautions measures to avoid further spread of the virus. © 2022 IEEE.

COVID-19 mortality risk assessments for individuals with and without diabetes mellitus: Machine learning models integrated with interpretation framework.

This research develops machine learning models equipped with interpretation modules for mortality risk prediction and stratification in cohorts of hospitalised coronavirus disease-2019 (COVID-19) patients with and without diabetes mellitus (DM). To this end, routinely collected clinical data from 156 COVID-19 patients with DM and 349 COVID-19 patients without DM were scrutinised. First, a random forest classifier forecasted in-hospital COVID-19 fatality utilising admission data for each cohort. For the DM cohort, the model predicted mortality risk with the accuracy of 82%, area under the receiver operating characteristic curve (AUC) of 80%, sensitivity of 80%, and specificity of 56%. For the non-DM cohort, the achieved accuracy, AUC, sensitivity, and specificity were 80%, 84%, 91%, and 56%, respectively. The models were then interpreted using SHapley Additive exPlanations (SHAP), which explained predictors' global and local influences on model outputs. Finally, the k-means algorithm was applied to cluster patients on their SHAP values. The algorithm demarcated patients into three clusters. Average mortality rates within the generated clusters were 8%, 20%, and 76% for the DM cohort, 2.7%, 28%, and 41.9% for the non-DM cohort, providing a functional method of risk stratification.

A novel framework integrating AI model and enzymological experiments promotes identification of SARS-CoV-2 3CL protease inhibitors and activity-based probe.

The identification of protein-ligand interaction plays a key role in biochemical research and drug discovery. Although deep learning has recently shown great promise in discovering new drugs, there remains a gap between deep learning-based and experimental approaches. Here, we propose a novel framework, named AIMEE, integrating AI model and enzymological experiments, to identify inhibitors against 3CL protease of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), which has taken a significant toll on people across the globe. From a bioactive chemical library, we have conducted two rounds of experiments and identified six novel inhibitors with a hit rate of 29.41%, and four of them showed an IC50 value <3 µM. Moreover, we explored the interpretability of the central model in AIMEE, mapping the deep learning extracted features to the domain knowledge of chemical properties. Based on this knowledge, a commercially available compound was selected and was proven to be an activity-based probe of 3CLpro. This work highlights the great potential of combining deep learning models and biochemical experiments for intelligent iteration and for expanding the boundaries of drug discovery. The code and data are available at https://github.com/SIAT-code/AIMEE.